Untangling the role
of IDH in Oncology
Stay in the know on IDH
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What is IDH?

IDH mutations cause overarching metabolic reprogramming
that results in dysregulation of1:

Gene expression

Intracellular trafficking

DNA damage repair

Aging

Inflammation

Cell death
Explore video clips on the function of IDH1 and the impact of mutation1,4–7

Overview of IDH1 and mutated IDH1 (mIDH1)

What is the normal function of IDH1?

What is the impact of mIDH1?
The Negative Impact of mIDH
in MDS and AML
The Negative Impact of mIDH in MDS and AML

Visualizing the Effect of
Mutations on Patient Risk
Visualizing the Effect of Mutations on Patient Risk
Using the IPSS-M Risk Calculator
The Importance of Expedited
Mutational Testing
Find a Test Center (Coming Soon)

Recent advances in mutational testing techniques and availability at commercial reference laboratories have improved turnaround times to as few as 3-5 days.22–24
Stay in the Know
Join our mailing list for the latest updates and available information.
References:
1. Pirozzi CJ and Yan H. Nat Rev Clin Oncol. 2021;18(10):645-661. doi:10.1038/s41571-021-00521-0
2. Phillips C. National Cancer Institute Website. https://www.cancer.gov/news-events/cancer-currents-blog/2022/idh1-cancer-metabolite-blocks-immune-cells. Accessed May 12, 2023. 3. RCSB Protein Data Bank website. https://doi.org/10.2210/pdb3MAP/pdb Accessed May 18, 2023. 4. Lu C, et al. Nature. 2012;483(7390):474-478. doi:10.1038/nature10860 5. Chowdhury R, et al. EMBO Rep. 2011;12(5):463-469. doi:10.1038/embor.2011.43 6. Wu N, et al. Biomol Ther. 2016;24(1):1-8. doi:10.4062/biomolther.2015.078 7. Losman JA and Kaelin WG. Genes Dev. 2013;27(8):836-852. doi:10.1101/gad.217406.113 8. Cairns RA and Mak TW. Cancer Discov. 2013;3(7):730-741. doi:10.1158/2159-8290.CD-13-0083 9. Medeiros BC,. Leukemia. 2017;31(2):272-281. doi:10.1038/leu.2016.275 10. Jin J, et al. PLoS ONE. 2014;9(6):e100206. doi:10.1371/journal.pone.0100206 11. Thol F, et al. Haematologica. 2010;95(10):1668-1674. doi:10.3324/haematol.2010.025494 12. DiNardo CD, et al. Leukemia. 2016;30(4):980-984. doi:10.1038/leu.2015.211 13. UpToDate® website. https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-myelodysplastic-syndromes-mds. Accessed February 24, 2023. 14. IPSS-M Risk Calculator website. https://mds-risk-model.com/. Accessed March 25, 2023. 15. Bernard E, et al. NEJM Evid. 2022;1(7)1-14. doi:10.1056/EVIDoa2200008 16. Aguirre LE, et al. Leukemia. Published online May 5, 2023. doi:10.1038/s41375-023-01910-3 17. Cazzola M. Hematology. 2022; (1):375-381. doi:10.1182/hematology.2022000349 18. Abbas S, et al. Blood. 2010;116(12):2122-2126. doi:10.1182/blood-2009-11-250878 19. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Myelodysplastic Syndromes V.1.2023. © National Comprehensive Cancer Network, Inc. 2023. All rights reserved. Accessed April 24, 2023. To view the most recent and complete version of the guideline, go online to NCCN.org 20. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Acute Myeloid Leukemia V.3.2023. © National Comprehensive Cancer Network, Inc. 2023. All rights reserved. Accessed April 24, 2023. To view the most recent and complete version of the guideline, go online to NCCN.org 21. Röllig C, et al. Blood. 2020;136(7):823-830. doi:10.1182/blood.2019004583 22. Neogenomics Website. https://neogenomics.com/test-menu/idh1. Accessed March 23,2023. 23. Labcorp.com website. https://www.labcorp.com/tests/481484/i-idh1-idh2-i-mutation-analysis. Accessed March 23,2023. 24. Questdiagnostics.com website. https://testdirectory.questdiagnostics.com/test/test-detail/31547/isocitrate-dehydrogenase-1-and-2-idh1idh2-mutation-analysis?cc=MASTER. Accessed March 23,2023.
NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

